I've used it to archive my 200+ DVD collection and so far, it has worked on 99.9% of my collection. I haven't used it for a 5G iPod so far, because I ain't got one, but the process is the same, you just have to make sure you're saving to MPEG-4 codec and don't exceed a max. pixel count of 230400 (640*360 or 512*450 depending on the original's ratio) and you should be fine. Their forum certainly has enough information on how to create iPod compatible videos with handbrake. It's a good tool, it's free and "does it all in one step".